Human Microbiota Biobank
Registration number: 977
Microbiota Biobank is
situated at Department of Microbiology, University
of Tartu, Estonia.
The biobank was registered in 2010 at World Data
Centre for Microorganisms (WDCM) as WFCC Estonian Human Microbiota
Biobank (collection No. 977, acronym HUMB).
Biobank was established in 1994 when the first microbiota samples and lactobacilli strains were collected
in frame of the Estonian-Swedish allergy study. From that time the same study
subjects have been repeatedly observed and sampled, and this study is planned
to continue. This unique cohort enables us to reveal the changes in microbiota in connection with the changes in age, health
and life environment.
the next years the biobank was supplemented with
numerous strains and microbiota samples in frame of
several (including international) research projects. Indigenous bacteria of
human microbiota ? lactobacilli and bifidobacteria form the most valuable part of the biobank but the collection contains also several
opportunistic pathogens. Hundreds of new strains and samples from
gastrointestinal, urogenital, respiratory tract,
mouth and skin from healthy and diseased newborns, children, adults and elderly
people are added to biobank each year.
patented probiotic lactobacilli as well as reference
strains obtained from other collections are also conserved in the biobank.
Research and development
research work is a significant part of the biobank ?
DNA extraction and identification, detection of genes and properties of the
strains, analysis of microbiota composition, updating
of the database, viability control and renewing of the strains etc.
Probiotic development is an important research field. In
collaboration with the Bio-Competence Centre of Healthy Dairy Products several
gastrointestinal probiotics have been developed ? Lactobacillus fermentum
ME-3 (strain and patent belongs to University of Tartu; the strain is in the
market as the dairy product brand Hellus), L. plantarum TENSIA®
(DSM 21380) and L. plantarum
INDUCIA® (DSM 21379) (the two latter strains and their patents belong to
Bio-Competence Centre of Healthy Dairy Products). In collaboration with
Competence Centre of Reproductive Biology and Medicine search for vaginal probiotics is going on. In collaboration with Stomatology Clinic a set of oral bacteria has been
collected that has a potential for development oral probiotics
against caries and periodontitis.
participate in the European Network for Gastrointestinal Health Research
(ENGIHR) that aims to bring together a wide spectrum of scientist and
professionals sharing their knowledge and expertise to address the current
challenges and issues related to the production and validation of gut health promoting
the biobank, several treatment guidelines have been
developed, Ph.D. and master’s theses commenced, and numerous research papers
published. By virtue of the biobank, the Department
of Microbiology had opportunity to participate in EU 5th, 6th and 7th FP
projects (Microfunction, Biodefence,